ACE and type 2 diabetes mellitus: In MARLINA-T2DTM, linagliptin elicited a placebo-adjusted, non-significant 6% reduction in albuminuria (95% CI − 15.0 to 3.0; P = 0.1954) after 24 weeks of treatment in individuals with T2D and early diabetic kidney disease who had residual albuminuria despite receiving ACE inhibitors or angiotensin-receptor blockers [50].