Two carcinoma datasets (breast and lung cancer) also displayed a universal E/M hybrid state with the co-expression of EPCAM and VIM. However, there also existed several differences in terms of the expression pattern of classical EMT-inducing TFs (Zeb1/2, Twist1/2, and Snai1/2): the hybrid state in lung cancer cells seemed to be more dependent on these TFs in comparison with that in breast cancer. The gene discussed is TWIST1; the disease is lung cancer.