Because humoral autoimmunity in RA is influenced by HLA-DRB1 SE and is reflected by ACPA and/or RF synthesis, we tested whether these three factors are interrelated with IgG hypogalactosylation and whether the relationship between IgG hypogalactosylation and inflammatory activity differs in RA subsets defined by HLA-DRB1 SE, ACPA, or RF. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.