LINC00210 and neoplasm: To further confirm the role of linc00210 in liver TIC self-renewal, we established linc00210 silenced cells using CRISPRi approach (Fig. 3h), followed by sphere formation, and found linc00210 silenced cells showed impaired sphere formation capacity (Fig. 3h), maintenance (Fig. 3i) and tumor propagation (Fig. 3j).