PGF and preeclampsia: Furthermore, in preeclampsia models, VEGF (Vascular Endothelial Growth Factor) and PlGF (Placental Growth Factor) exhibit a proangiogenic role, whereas sFlt-1 (soluble form of the receptor for VEGF) acts as an antagonist of VEGF and PlGF, resulting in endothelial cell dysfunction and vasoconstrictor effects in maternal circulation [23].