Among the genes differentially expressed between the tumor and nontumorous areas that showed the strongest correlation with HCV RNA levels, we focused on the tumor-associated calcium signal transducer 2 (TACSTD2), a gene previously reported to be important for the proper cellular localization of CLDN1 and OCLN in human corneal epithelial cells [21]. The gene discussed is TACSTD2; the disease is neoplasm.