TACSTD2 and infection: To study whether TACSTD2 affects infection by different HCV genotypes and subgenotypes, we tested the effect of TACSTD2 gene silencing on infection by a series of luciferase-expressing chimeric viruses representing all HCV genotypes and two subgenotypes, namely, 1a, 1b, 2b, 3a, 4a, 5a, 6a, and 7a [38, 39].