We found that increased levels of circulating ANGPTL3 were positively associated with liver dysfunction and inflammation, elevated ANGPTL4 levels were positively associated with impaired glycometabolism and liver dysfunction and inversely correlated with inflammation, and increased ANGPTL8 levels were associated with obesity, impaired glycometabolism, and dyslipidemia. The gene discussed is ANGPTL8; the disease is metabolic syndrome.