We found that increased levels of circulating ANGPTL3 were positively associated with liver dysfunction and inflammation, elevated ANGPTL4 levels were positively associated with impaired glycometabolism and liver dysfunction and inversely correlated with inflammation, and increased ANGPTL8 levels were associated with obesity, impaired glycometabolism, and dyslipidemia. This evidence concerns the gene ANGPTL8 and obesity due to melanocortin 4 receptor deficiency.