Although inflammation plays crucial roles in progression of metabolic diseases such as obesity or impaired glycometabolism [25], a positive correlation between inflammation and circulating ANGPTL3 remained statistically significant after adjustment for variables including obesity, impaired glycometabolism, dyslipidemia and hypertension, suggesting that circulating ANGPTL3 is independently associated with inflammation. The gene discussed is ANGPTL3; the disease is hypertensive disorder.