ANGPTL3 and obesity due to melanocortin 4 receptor deficiency: Although inflammation plays crucial roles in progression of metabolic diseases such as obesity or impaired glycometabolism [25], a positive correlation between inflammation and circulating ANGPTL3 remained statistically significant after adjustment for variables including obesity, impaired glycometabolism, dyslipidemia and hypertension, suggesting that circulating ANGPTL3 is independently associated with inflammation.