EDNRA and dementia: In addition to the variety of autoantibodies (AABs) detected in patients with dementia and suggested to be pathogenic players, biomarkers and treatment targets such as those summarized in [1,2], there is a new class of autoantibodies, the so-called functional autoantibodies that are directed against G-protein coupled receptors (GPCRs; GPCR-AABs) which are increasingly seen as pathogenic players.