In addition, 15 patients (8 PTCL-not otherwise specified (NOS), 3 ALK+ anaplastic large cell lymphoma (ALCL), 3 extranodal NK/T cell lymphoma (ENKL), 1 enteropathy-type T-cell lymphoma (EATL)) who had CNS involvement at initial diagnosis were also excluded, leaving a total of 600 patients for final analysis (S1 Table). The gene discussed is ALK; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.