The development of tissue damage also coincided with the onset of clinical signs (Fig 2B–2D), and is possibly driven by the strong activation of NF-kb mediated responses that lead to high levels of macrophage and neutrophil infiltration in the lung, a scenario that is commonly found in respiratory infections of viral origin [8, 9, 21, 32, 36]. The gene discussed is NFKB1; the disease is respiratory tract infectious disorder.