SLCO1B1 and spindle cell hemangioma: In OATP1B1- and OATP1B3-expressing stable cell lines and human SCH, treatment with lysosome inhibitor chloroquine markedly increased protein levels of OATP1B1 and 1B3, suggesting that the lysosome plays an important role in degradation of OATP1B1 and OATP1B3 [138,161].