PTEN and hepatocellular carcinoma: Signaling pathways predicted to be regulated in HCC by miR-21 targets include inhibition of acute phase response signaling, the liver X receptor/retinoid X receptor (LXR/RXR) pathway, the peroxisome proliferator-activated receptor alpha/retinoid X receptor alpha (PPARα/RXRα) pathway, phosphatase and tensin homolog (PTEN) signaling, and upregulation of Tec kinase signaling (Adjusted p-value < 0.0005, Figure 4D).