Knockdown of the autophagy regulators autophagy-related 3 (ATG3), ATG5 or ATG7 stimulates the migration of mouse embryonic fibroblast (MEF) and HeLa cells [14], and autophagy activation is associated with the degradation of Snail, a protein that regulates epithelial-mesenchymal transition (EMT) in breast cancer models [15]. The gene discussed is ATG3; the disease is breast carcinoma.