Consistent with the results of the in vitro experiments, the immunohistochemical staining showed that SH treatment dramatically increased the levels of p21 and CHOP, increased the numbers of LC3B puncta and decreased the levels of proliferating cell nuclear antigen (PCNA), MMP-2/-9, NFκB p65, vimentin, Snail and Slug in tumor tissues compared to the control group (Figure 6). The gene discussed is DDIT3; the disease is neoplasm.