In particular, it would be interesting to test in this context the effect of omega 3 PUFAs on mitochondrial cardiolipin and/or Ca2+ flux between ER and mitochondria to elucidate whether omega 3 PUFA reverse or inhibit these mechanisms suggested to be involved in induction of NLRP3 inflammasome and insulin resistance onset. This evidence concerns the gene NLRP3 and Insulin resistance.