Noteworthy, omega 3 PUFA supplementation (100 mg/kg, twice a week for 10 weeks) also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes mouse model, revealing a mechanism through which omega 3 PUFA repress inflammation and prevent inflammation-driven diseases, such as insulin resistance [111]. This evidence concerns the gene NLRP3 and metabolic disease.