Omega 3 PUFA have been recently proposed as modulators of nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome in obesity and obesity-related metabolic diseases, such as insulin resistance [111], and it has been suggested a putative involvement of mitochondria in this modulation [112]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.