IRF4 and infection: Then, we checked for transcriptomic differences associated with genotype and/or infection, by investigating the transcriptomes of PBMCs from six IRF4-heterozygous individuals (three patients, P1-P3; and three healthy relatives, HET1-HET3) and six IRF4 WT-homozygous individuals (four healthy relatives, WT1-WT4; and two healthy unrelated controls, C1-C2) with and without in vitro infection for 24 hr with Tw, or Mycobacterium bovis-Bacillus Calmette-Guerin (BCG), which, like Tw, belongs to phylum Actinobacteria.