CSNK1A1 and early-onset autosomal dominant Alzheimer disease: Aberrant functional regulation of CK1, such as its over-expression or excessive activation, is implicated in the pathogenesis of many diseases including several neurodegenerative disorders, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).1