The role of activated NOTCH signalling and TGFβ has also been shown in liver fibrosis.54 Once the intracellular domain of the NOTCH protein (NICD) is transported into nucleus, it can interact with a number of different transcription factors, including FoxH1, c‐Jun, c‐Fos, Gli‐3 and others and control expression of a large number of target genes, including, for example, genes involved in cell cycle control, extracellular matrix regulation and mesoderm specification. This evidence concerns the gene TGFB1 and Hepatic fibrosis.