ITGB2 and atherosclerosis: Development of atherosclerosis is initiated by adhesion of monocytes as well as T lymphocytes to the arterial endothelial surface, followed by their migration into the subendothelial space.11 Leukocyte Function-associated Antigen-1 (LFA-1), consisting of CD11a and CD18 subunits, is an integrin cell-surface receptor expressed on leukocytes.