In the last 17 years (2000–2016), it has been noted that patients with intracranial complications of sinusitis, aside from those with subdural empyema, have only moderately expressed neurological symptoms, show a more rapid normalisation of biochemical blood markers (leukocytosis, CRP and procalcitonin) and return to health more quickly than patients in earlier years, e.g. 1964–1999. This evidence concerns the gene CRP and sinusitis.