CRP and Increased total leukocyte count: In the last 17 years (2000–2016), it has been noted that patients with intracranial complications of sinusitis, aside from those with subdural empyema, have only moderately expressed neurological symptoms, show a more rapid normalisation of biochemical blood markers (leukocytosis, CRP and procalcitonin) and return to health more quickly than patients in earlier years, e.g. 1964–1999.