According to the cBioPortal for Cancer Genomes (http://www.cbioportal.org/), somatic mutations in the APC and CTNNB1 loci have rarely been identified in pancreatic cancer, but a few CTNNB1 gene mutations have been reported in cases of pancreatoblastoma [4–7]. This evidence concerns the gene CTNNB1 and Pancreatoblastoma.