Recently, Lyp-1 based Lyp-1-anti-DTPA bispecific antibody complex (Lyp-1-bsAbCx) and Lyp-1-doxorubincin (Dox-Lyp-1) drug conjugates and others have been generated for in vitro analysis of cytotoxicity in MDA-MB-231 breast cancer cells and Dox-Lyp-1 conjugates have been found to be more efficient than free doxorubicin [149]. The gene discussed is PTPN22; the disease is breast cancer.