Thus, armed with the knowledge of oncogenic splicing factors such as SRSF1 and hnRNPs being overexpressed in various cancers with constitutively active growth survival signals [110] and the reported co-purification and correlation with HABP1/p32 [24] we embarked upon discerning the regulatory role of SRSF1 in hepatocarcinoma cell lines HepG2 and HepG2 cell line stably overexpressing HABP1 (HepR21). This evidence concerns the gene SRSF1 and cancer.