ALK and melanoma: In a more recent study of melanomas published in 2015, Wiesner et al. reported the existence of I19-containing ALK transcripts in which only the 3′ end of I19, approximately 400 bp in length, represents the beginning of the ALK transcript and producing a novel initiation transcription site; these aberrant ALK transcripts were found in 11% of their cohort of melanomas [23].