Our study results demonstrating a higher incidence of microhemorrhages in the ventral horn vs. the dorsal horn in the lumbar segments of media-treated symptomatic ALS mice, potentially leading to motor neuron loss, are supported by previously published data [31] showing significantly more hemosiderin deposits in the anterior horn than in posterior horn of the lumbar spinal cord of different SOD1 mutant mice even at pre-symptomatic disease stage. Here, SOD1 is linked to amyotrophic lateral sclerosis.