NFATC1 and Sepsis: However, as other members of NFAT (NFATc1, NFATc2 and NFATc4) are not activated in macrophages during LPS stimulation and NFATc3 is not activated in lung PMVEC and alveolar type II epithelial cells, the observed decrease in sepsis-induced pulmonary edema can be attributed to macrophage specific NFATc3 activation.