Comparison of LPS stimulated NFATc3−/− and WT BMDM gene expression indicated distinct down regulation of LPS induced CCR2 and TNFα in NFATc3−/− macrophages (Figure 2A–2B), suggesting that NFATc3 regulates macrophage gene expression thereby regulates pathogenesis of sepsis induced-ALI. This evidence concerns the gene TNF and acute respiratory distress syndrome.