For example, while VEGF is certainly a crucial factor in angiogenesis and several studies have indicated circulating VEGF as a prognostic biomarker in CRC, the lack of predictive value of proangiogenic proteins in our study is consistent with prior studies that failed to demonstrate the predictive ability of biomarkers including VEGF for anti-VEGF therapy in CRC patients [7, 15, 45, 47]. Here, VEGFA is linked to colorectal carcinoma.