NOK co-cultured with EBV-negative BL cells did not show any increase in invasion or LEF1 and WNT5A mRNA and protein levels over the parental uninfected population (Supplementary Figure 2), suggesting that the invasive phenotype and changes in LEF1 and WNT5A expression were due to EBV infection. This evidence concerns the gene LEF1 and Epstein-Barr virus infection.