TGFB1 and systemic sclerosis: Pharmacological inhibitors of CDK5 prevented and reversed TGF-β-induced stimulation of collagen synthesis and myofibroblast differentiation in fibroblast-monolayer cultures and in ex vivo skin organ cultures, ameliorated collagen overproduction in SSc fibroblasts, and prevented and reversed skin fibrosis in complementary inflammatory and TGF-ß-driven mouse models of SSc.