Of particular current interest is the emerging role of CDK5 in obesity, since PPAR-γ, the essential master regulator of adipogenesis required for mature adipocyte differentiation adipokine production [20, 21], was recently found to be a major substrate for CDK5-mediated phosphorylation and inactivation [22, 23]. This evidence concerns the gene CDK5 and obesity due to melanocortin 4 receptor deficiency.