Regarding influence of comorbidity, levels of 5 mC, H4PanAc, H3K9Ac, H3S10PO4, H3K36Me3, EZH2, HMGB1 and CEA (lung disease), H3K9Me3 and pH2AX (cardiovascular disease), and H3K9Me3 (diabetes I/II) were significantly lower in individuals with comorbidity compared to levels in individuals with no comorbidity and clean colorectum; R2 < 0.05 (Table 1). Here, HMGB1 is linked to lung disorder.