AKT1 and breast cancer: One example is the long intergenic non-coding RNA for kinase activation, Link-A (linc01139, (Δlog2 = 6.83, padj = 1.8 × 10−4), is highly expressed in breast cancer and has been shown to specifically interact with phosphatidylinositol 3,4,5-trisphosphate (PIP3) and Protein Kinase B (PKB/AKT) [71].