HULC, first shown to be very upregulated in HCC over ten years ago [20] upregulated in cholangiocarcinoma [61], and is upregulated by PKA phosphorylation of CREB [62], as well as in many cancers leading to the proposal that it is a prognostic biomarkers for human cancers [63]. This evidence concerns the gene CREB1 and hepatocellular carcinoma.