SPARC and glioblastoma: In contrast, mRNA expression of both microglia markers Iba1 and Sparc was significantly increased in GBM specimens in comparison to nonmalignant brain tissue from 1.37 (Min–Max: 0.14–4.54) to 6.53 (Min–Max: 0.27–57.73) for Iba1 and from 0.94 (Min–Max.: 0.44–5.10) to 4.82 (Min–Max: 0.28–35.97) for Sparc.