The low responders, Ghs6 and M15.2 (Figures 4C,D, respectively), differ especially due to the downregulation of one or more of these genes, STAT1, CCL5, and IRF1, was predicted to increase viral replication and infection in the Ghs6 and M15.2 sublines (QIAGEN, 2014). The gene discussed is IRF1; the disease is infection.