There is some evidence in the literature linking vitamin A itself and genes related to vitamin A, e.g., retinoic acid receptor alpha, RARA, with the risk of orofacial clefts (Rothman et al., 1995; Mitchell et al., 2003; Bille et al., 2007; Johansen et al., 2008; Boyles et al., 2009; Skare et al., 2012). Here, RARA is linked to orofacial cleft.