Pathogenic autoantibodies [pemphigus autoantibodies (PVIgG)] in sera from pemphigus patients target predominantly molecular components of the desmosomes, such as desmoglein (Dsg)3 [pemphigus vulgaris (PV)] and Dsg1 [pemphigus foliaceous (PF)] [reviewed by Stanley and Amagai (2)]. The gene discussed is DSG3; the disease is pemphigus.