In addition to validating the effect of NLRX1 on inflammation and epithelial cell proliferation in a separate model of disease, we elucidate epithelial cell intrinsic pathways that contribute to worsened disease severity and may also help to further define the linkage between NLRX1 and NF-κB signaling or NLRX1 and cancer. Here, NFKB1 is linked to cancer.