Many of these microbial changes observed in NLRX1−/− mice have also been linked to the gut microbiomes associated with CD, primary sclerosing cholangitis, and other digestive inflammatory disorders, specifically, the downregulation of Bacteroidetes and the expansions of Veillonella and Porphyromonas (49–51). This evidence concerns the gene NLRX1 and sclerosing cholangitis.