We previously showed that adoptive transfer of IL-10-transduced T cells from chicken OVA-specific TCR transgenic DO11.10 mice ameliorated methylated bovine serum albumin (BSA)-induced arthritis when the arthritic joint was co-injected with OVA in addition to methylated BSA without impairing the systemic immune response to the antigen. Here, IL10 is linked to arthritic joint disease.