CASP3 and cancer: A strong parallel exists with wound healing in that the proliferative effect of apoptotic cells in both cancer and wound healing strongly depended on caspase-3-mediated activation of calcium-independent phospholipase A2 (iPLA2) and the iPLA2-mediated generation of prostaglandin E2 (PGE2; refs. 16, 22, 52, 77, 78).