Soluble intercellular adhesion molecule-1 (sICAM-1), matrix metalloproteinase-3, N-terminal pro-B-type natriuretic peptide, interleukin-6 (IL-6), soluble CD40 ligand, and insulin-like growth factor binding protein-2, as well as age and diabetes mellitus, were found strongly associated with death and myocardial infarction (15). The gene discussed is IL6; the disease is diabetes mellitus.