Recent studies have shown that MFGE8, which promotes phagocytosis and inhibits inflammation, is an endogenous protective factor in response to brain infarction (17, 18), Alzheimer’s disease (19, 20), subarachnoid hemorrhage (SAH) (16), and prion disease (21). The gene discussed is MFGE8; the disease is early-onset autosomal dominant Alzheimer disease.