In addition to the well-known target of As2O3 in APL, the PML-RARAα fusion protein (Goto et al., 2011; Tomita et al., 2013; Chendamarai et al., 2015; Lou et al., 2015; Liu J. et al., 2016), numerous other determinants of resistance have been described in the literature (Table 5). Here, PML is linked to acute promyelocytic leukemia.