Previous studies have demonstrated that LPS could induce ALI by activating TLR4/NF -κB signaling pathway,which regulates the transcription of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α (Wu et al., 2016).These cytokines can induce innate immune response and cause serious injury to the lung tissues, ultimately result in ALI (Herold et al., 2011; Gandhi and Vliagoftis, 2015). The gene discussed is TLR4; the disease is acute respiratory distress syndrome.