Actually, Jab1/COPS5 overexpression was reported in many kinds of cancers, including hepatocellular carcinoma (HCC) (Hsu et al., 2008b), pancreatic cancer (Kouvaraki et al., 2006), breast cancer (Kouvaraki et al., 2003), non-small cell lung cancer (NSCLC) (Osoegawa et al., 2006), nasopharyngeal carcinoma (NPC) (Pan et al., 2012), and many others (Pan and Claret, 2012; Pan et al., 2014). Here, COPS5 is linked to hepatocellular carcinoma.