COPS5 and hepatocellular carcinoma: Indeed, accumulating evidence has shown the inverse association between Jab1/COPS5 and p27 expression in various human malignancies, including HCC (Berg et al., 2007), NPC (Pan et al., 2012), oral squamous cell carcinomas (Gao et al., 2012) and papillary thyroid carcinoma (Ahn et al., 2009).