Patients with Jab1/COPS5 overexpression tended to have larger tumor size in thyroid carcinoma and poor overall survival in oral squamous cell carcinoma, NPC, and laryngeal squamous cell carcinomas, indicating its critical role in head and neck cancer (Dong et al., 2005; Ahn et al., 2009; Gao et al., 2012; Xu et al., 2015). Here, COPS5 is linked to neoplasm.