In addition to this, several studies documented reduced expression of astrocyte specific glutamate transporter genes (EAAT1, EAAT2 or SLC1A2, SLC1A3) in the orbitofrontal cortex (Miguel-Hidalgo et al., 2010), dorsolateral PFC (Choudary et al., 2005; Zhao et al., 2016), hippocampus (Medina et al., 2013, 2016) and locus coeruleus (Bernard et al., 2011; Chandley et al., 2013) of patients with MDD. This evidence concerns the gene SLC1A2 and major depressive disorder.