McNee et al. [9] recently identified that peptidyl arginine deiminase 2 (PADI2) was one of the most highly upregulated transcripts, in MSCs from both MGUS and MM patients, that could induce upregulation of IL-6 through its enzymatic deimination of histone H3 arginine 26. Here, PADI2 is linked to Miyoshi myopathy.