CCR1 and Miyoshi myopathy: In addition, Vallet et al. [91] reported that MM cell-derived CCL3 exerted a strong inhibition of osteoblast function and that treating SCID-hu mice with an inhibitor of the corresponding chemokine (C-C motif) receptor 1 (CCR1) induced an upregulation of osteocalcin expression along with osteoclast downregulation.