Moreover, high DDX27 staining predicted poor overall survival for patients with early stage (I and II) colon cancer in Shanghai cohort, as evidenced by Kaplan-Meier survival analysis (P < 0.05, Fig. S1E) and multivariate analysis (P < 0.05; hazard ratio: 1.860; 95% CI, 1.064–3.250; Table S12). Here, DDX27 is linked to malignant colon neoplasm.