To gain insights into the molecular mechanisms underlying pro-tumorigenic action of DDX27, we screened several important cancer pathways by luciferase reporter assays, including nuclear factor-кB (NF-кB), Wnt/β-catenin (TOPflash/FOPflash), STAT3 (APRE), p53, p38, p21, TGF-β and STAT5 (LHRE) signaling pathways. Here, STAT3 is linked to cancer.