In an effort to use Drosophila melanogaster as a model organism for characterizing UCHL1 functions in the pathogenesis of PD, we initially aligned Drosophila Ubiquitin C-terminal hydrolase (dUCH, P35122, CG4265) protein with human UCHL1 (hUCHL1, P09936) and mouse UCHL1 (mUCHL1, Q9R0P9). This evidence concerns the gene UCHL1 and Parkinson disease.