INS and Hypoglycemia: However, in one trial that permitted the concomitant use of anti-diabetic agents associated with hypoglycemia, hypoglycemic episodes were reported much higher in the subgroup of patients who were taking background insulin or insulin secretagogues (29/87 vs. 12/74 in the treatment and control group, respectively) than those among the patients not on insulin or insulin secretagogues (1/24 vs. 0/28 in the treatment and control group, respectively)11.