In a more focused comparison with the most frequent neuroendocrine type of lung cancer, SCLC, type I LCNECs with STK11 and KEAP1 alterations exhibited a high degree of similarity with these carcinomas, as well as high expression of neuroendocrine genes and a profile of ASCL1high/DLL3high/NOTCHlow. The gene discussed is KEAP1; the disease is lung cancer.