Although, LCNECs also harbored alterations commonly observed in adenocarcinomas and squamous cell carcinomas, even LCNECs with such alterations in KEAP1 or STK11 were primarily found in transcriptional subclasses shared with SCLC (Fig. 2a, Supplementary Fig. 7c, Supplementary Data 12). This evidence concerns the gene KEAP1 and adenocarcinoma.