Consistent with this notion, we found that type II LCNECs and some SCLC within this transcriptional class exhibited signs of NOTCH upregulation and low expression of neuroendocrine markers, ASCL1 and DLL3, an inhibitor of the Notch signaling pathway37 (Fig. 3d, and Supplementary Fig. 12f). This evidence concerns the gene DLL3 and small cell lung carcinoma.