CHGA and small cell lung carcinoma: The most striking difference was found in the expression levels of neuroendocrine genes: while type I LCNECs and the majority of SCLC tumors (class III + IV) harbored high levels of neuroendocrine genes (CHGA and SYP; Fig. 3c; Supplementary Fig. 12e; Supplementary Data 12), most LCNECs and some SCLC tumors with RB1 alterations in class II exhibited low levels of these genes (Fig. 3c, Supplementary Fig. 12e).