These genes include AURKB, BUB1, CHEK1, FOXM1, KIFC1, and TTK7, five of which, BUB1, CHEK1, FOXM1, KIFC1, and TTK, we have also identified and have functionally validated to have a selective requirement for cell growth in breast cancer cell models. The gene discussed is BUB1; the disease is breast cancer.