Furthermore, comparison of validated hits and data from the COLT-Cancer data12 found concordance between our siRNA NPI scores and the zGARP shRNA scores for 11 genes (BUB1B, CHEK1, FOXM1, GABRP, MYBL2, PRKDC, PSMD4, S100A9, GPR89, FANCL, GNB4) (Supplementary Data 11). The gene discussed is PRKDC; the disease is cancer.