RHNO1 and cancer: Our data suggest that as well as being individually essential for TNBC survival, a substantial proportion of TNBCs rely on the function of specific genes within common cellular processes: such as the DNA damage response (CHEK1, DTL, RHNO1, and UBE2T); transcriptional regulation of the cell cycle as in the case of FOXM1, LIN9, and MYBL2 which control the DREAM/LINC complex known to regulate entry/exit from quiescence and cancer cell proliferation27; and mitosis (BUB1, BUB1B, KIFC1, MASTL, NUF2, and TTK).