Within the largest cluster, recurrent across external data sets, we focus on a potential drug target the kinesin family member C1 (KIFC1/HSET) and show that KIFC1 is a selective essential gene for many malignant breast cancer cells, demonstrating the mechanism of addiction to be based upon clustering of abnormal multiple centrosomes relevant to the majority of TNBCs that have centrosome amplification13. Here, KIFC1 is linked to breast carcinoma.