This corresponds to high densities of CD8(+) cells and/or low microvessel densities, which as separate properties have been shown to be associated with good prognosis in prostate cancer in the literature: The hypothesis that CD34-based microvessel density is a significant predictive and prognostic factor is widely accepted and confirmed by various studies60,61, while the prognostic properties of tumor-infiltrating lymphocytes are more differentiated. This evidence concerns the gene CD8A and prostate cancer.