Our data further show that infection with RSV, HRV14, and HRV16 also causes temporally defined release of serum HMGB1; however, the strength of HMGB1 release in RSV-infected animals was stronger than that in HRV14- and HRV16-infected animals and comparable to animals infected with influenza A and B viruses (Fig. 3A and B). The gene discussed is HMGB1; the disease is infection.